British oncologist proposes new treatment for mesothelioma

Medical oncologist Dr. Angus Dalgleish never liked standard care therapy for pleural mesothelioma cancer, even if he has reluctantly recommended it in the past.

He believes there is something better now.

Dalgleish, of St. George’s Hospital, University of London, recently published a case report describing a new treatment regimen that changed a patient’s life expectancy from six months to six years of survival.

Treatment included a range of anti-inflammatories, including low-dose naltrexone, vitamin D3 supplements, and the IMM-101 vaccine, which boosts a patient’s own immune response.

“At first I was pleasantly surprised at how well this worked, but it made sense,” Dalgleish told The Mesothelioma Center on Asbestos.com. ‘We have seen positive signs in other tumors. This certainly deserves a closer look mesotheliomaIt can become very important. “

His findings were published in Respiratory Medicine Case Reports.

Mesothelioma patient chooses quality of life

The case involved a 64-year-old man in the United Kingdom diagnosed with epithelioid mesothelioma and pleural effusions, lung nodules and enlarged thoracic lymph nodes. His original oncologist recommended it aggressively pleurectomy and decortication surgery, along with adjuvant chemotherapy and possibly radiation.

Instead, the patient turned to Dalgleish for advice.

“He was very concerned about quality of life if he received the recommended treatment, and I agreed,” said Dalgleish. “Aggressive treatment, sometimes for this disease, is like throwing fuel on the fire. I have often said, “Why are we doing this to patients?” It’s like entering a room and kicking a sleeping Rottweiler. It does not make any sense. “

Dalgleish had seen positive results using the vaccine in combination with chemotherapy as part of a study for the treatment of pancreatic cancer. It is known as an immune modulator, which enhances a patient’s immune response, but also dampens a negative system response.

Dalgleish Report Shows Anti-Inflammatory, Vitamin D3 Help

Dalgleish had done extensive research with other cancers on the benefits of maximizing the anti-inflammatory response. He always believed that common vitamin D3 deficiencies in elderly patients reduced the effectiveness of cancer treatment.

And he previously knew two mesothelioma patients who were enrolled in a lung cancer clinical trial studying a similar regimen. They did better than expected.

‘I had reason to believe this [regimen] could be effective, ”he said. “And it certainly was in this case.”

A year after the patient started treatment, a CT scan showed no tumor progression, making him much longer than his initial life expectancy.

Three years later, another CT scan showed slow tumor progression, prompting him to start taking zoledronic acid, which is often used by cancer patients to combat elevated calcium levels. He also underwent local radiotherapy for an enlarged chest wall lesion where the original biopsy was performed.

UK patient wanted his treatment story to be told

The patient later started using cannabis oil but was not taking any other treatment drugs. He died in 2019, six years after his original diagnosis.

However, he died of a disease that had migrated to his peritoneal cavity and not the tumor burden originally found in his chest.

Dalgleish believes there will be other mesothelioma patients willing to bypass standard care to further study a similar treatment regimen in a clinical trial

He estimated that one third of that pleural mesothelioma Patients in the United Kingdom opt for standard care because the survival benefit is minimal and the resulting drop in quality of life is significant.

“There really isn’t anything approved that works well enough that I’d like to take,” he said. “It’s very marginal and quite toxic. Why not try something else? “

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